After adjusting for age, the serum uric acid level in the highest quintile group of total dairy food intake was lower than that in the lowest by 0.21 mg/dl (95% CI 0.04, 0.37; P = 0.02 for trend). After adjusting for other covariates, the difference between the extreme quintiles remained similar (P = 0.005 for trend) (Table 2). Those who consumed milk ?1 time per day had a lower serum uric acid level than did those who did not drink milk (multivariate difference –0.25 [95% CI –0.40, –0.09]; P < 0.001 for trend) (Table 3). Similarly, those who consumed yogurt at least once every other day had a lower uric acid level than did those who did not consume yogurt (multivariate difference ?0.26 [95% CI ?0.41, ?0.12]; P < 0.001 for trend).
Such associations was in fact separate of both the other diet products i learned therefore the other chance products to have hyperuricemia, instance age, sex, Body mass index, gel creatinine peak, hypertension, alcohol fool around with, and you can diuretic use
The results from logistic regressions with hyperuricemia because the an excellent dichotomous result were equivalent. Such as for example, the multivariate odds proportion (OR) to own hyperuricemia one particular regarding the large quintile number of chicken intake as compared with those who work in a low quintile is actually 1.37 (95% CI 1.05, step 1.80; P = 0.027 to own pattern) therefore the involved And for dairy intake try 0.74 (95% CI 0.55, 0.99; P = 0.05 for pattern). The new multivariate ORs getting hyperuricemia was step one.58 (95% CI step one.07, 2.34; together2night P = 0.11 for trend) for seafood usage between more a 1 / 2 every day serving and you can none, and you can 0.66 (95% CI 0.forty eight, 0.89; P = 0.011 getting trend) for whole milk application anywhere between >step 1 daily serving and you will none.
The fresh new solution the crystals peak increased having growing healthy protein intake when you look at the age-modified study (P = 0.006 to possess trend). not, shortly after modifying with other covariates, overall protein intake try no more from the gel uric acidic level (Dining table 2). When we repeated the analysis having fun with energy-modified proteins thinking ( sixteen ) instead of the part of opportunity, the outcome didn’t materially alter (P = 0.72 to possess development).
When we repeated our analyses for foods or protein after excluding participants who self-reported gout or were taking allopurinol or uricosuric agents, the results did not materially change. 27 for interaction for all comparisons). The serum uric acid level in the highest quintile group of dairy food intake was lower than that in the lowest quintile by 0.14 mg/dl (95% CI 0.03, 0.25) among those with a BMI <25 kg/m 2 and by 0.30 mg/dl (95% CI 0.13, 0.47) among those with a BMI ?25 kg/m 2 (P = 0.13 for interaction).
Within across the country representative shot of men and women, brand new solution the crystals peak is actually discovered to help you significantly raise that have broadening usage of animal meat and seafood however which have full proteins intake. Simultaneously, we located a significant inverse organization having dairy consumption.
The current investigation results advise that the consumption of meat and you can seafood inside the number reflective of all over the country intake develops serum accounts out-of uric acid. In past times, the hyperlink has been primarily extrapolated out of animal or individual metabolic tests that checked-out the brand new impression of brief-title artificial loading of filtered purine (instead of actual ingredients) on the serum the crystals top ( 4-7 ). not, the precise label and you may level of individual purines for the majority edibles aren’t really-known, especially when cooked otherwise canned ( 8 ), and also the bioavailability of various purines present in other snacks may differ drastically. Particularly, slimming down replacing/introduction studies showed that RNA possess an elevated influence on new solution the crystals top than really does an identical number of DNA ( eight ), ribomononucleotides greater than nucleic acid ( 17 ), and you will adenine greater than guanine ( 4 ). Thus, it’s been hard to anticipate if a generally ate eating or eating classification in fact has an effect on brand new serum the crystals height, and if so, after that because of the just how much. The modern investigation actually connected well-known delicacies and you will serum the crystals levels while offering the relevant guidance.